Hsueh-Chi Sherry Yen is a Research Fellow in the Institute of Molecular Biology at Academia Sinica and a Professor of the Genome Science Degree Program at National Taiwan University.  She was awarded a Ph.D. from New York University and was a Jane Coffin Childs Postdoctoral Fellow at Harvard Medical School.  She has a long-standing interest in understanding ubiquitin-proteasome-mediated protein degradation.  Specifically, she has developed GPS (global protein stability) profiling technology for high-throughput characterizations of protein degradation in living cells and she pioneered the discovery of C-degron pathways (C-end rule) that play a critical role in the elimination of erroneous proteins that arise from translation errors, protein missegregation and proteolytic cleavage.