Prof Stefan Knapp

University of Frankfurt

Stefan Knapp studied chemistry at the University of Marburg (Germany) and the University of Illinois (USA). He received his Ph.D. in protein crystallography from the Karolinska Institute in Stockholm. He joined Pharmacia (Nerviano, Italy) in 1999 and left the company in 2004 to establish a research group at the Structural Genomics Consortium at the University of Oxford. From 2008 to 2015 he was Professor of Structural Biology at Oxford University (UK) and from 2012 to 2015 Director of Chemical Biology at the Target Discovery Institute at Oxford University. In 2015, he joined the University of Frankfurt as Professor of Pharmaceutical Chemistry. Since 2017, he is also the CSO of the SGC (Structure Genomics Consortium) node at Goethe University Frankfurt. His research interests are the elucidation of molecular/structural mechanisms of kinase regulation using high resolution structures, the design of selective kinase inhibitors, and the inhibition of protein interaction domains including bromodomains, which are the main readers of the epigenetic acetylation code, and E3 ligases.